Louisa was born 18 May 1829 in Tennessee, presumably the Nashville area. She is the eldest daughter of William Mann and Lucinda McKinney.
It is unknown when the family made the journey from Tennessee to Alabama, but the her father, William Mann, can be found there in the 1840 Federal Census. The location is only noted as the 'South Half of Madison County'. Children's names were not listed in 1840 but it is assumed that Louisa is the female child between the ages of 10 and 15.
Louisa was married 23 Oct 1845 in Madison County, Alabama, to James Madison Cloud. I have not ordered a copy of this record but the indices for the record can be found on the Madison County website HERE. In the indices Louisa is listed as Louisa Mans. She was only 15 years old when she married James.
The only census record found with Louisa listed by name is the 1850 Federal Census. In this census Louisa and James are living in District 35, Madison County, Alabama. She has two children at this time, Sara Elizabeth and Louisa Jane. Below is a print of the the 1850 Census. You can see that James and Louisa are surrounded by family. They are family #261. Family #260 is James' brother, Durgan Cloud, family 262 are Louisa's parents, William and Lucinda, and family #263 are Louisa's grandparents (Lucinda's parents), Thomas and Jane McKinney.
From the 1850 Census we can see that James and Louisa's first born child, Sarah Elizabeth Cloud, was born in Tennessee. So sometime after the couple were married in 1845 they must have spent some time back in Tennessee before coming back to Alabama. All the families are farming in 1850.
Louisa dies in Cloud Cove Valley, Madison County, Alabama 6 August 1853. She was only 23 years old. Louisa gave birth to two more children before her death, Maria and James. Below is her obituary.
It is not known where Louisa is buried in Madison County.
The blog for James Madison Cloud recaps the children born to him and Louisa.